All the ones I mentioned can be installed with pip or uv if I am not mistaken. It would probably be more finicky than containers that you can put behind a reverse proxy, but it is possible if you wish to go that route. Ollama will also run system-wide, so any project will be able to use its API without you having to create a separate environment and download the same model twice in order to use it.

Ollama for API, which you can integrate into Open WebUI. You can also integrate image generation with ComfyUI I believe.

It’s less of a hassle to use Docker for Open WebUI, but ollama works as a regular CLI tool.